BPC-157

BPC-157 (Body Protection Compound-157) is a synthetic peptide of 15 amino acids, studied in research as a fragment related to larger gastric-derived peptide systems. In the published literature it is generally evaluated for its effects on cellular processes involved in barrier integrity, tissue response to injury and vascular adaptation in controlled models.

Research applications

BPC-157 appears in preclinical studies of wound models, tendon outgrowth and cell migration, gastrointestinal tissue models and angiogenesis assays. Most published work uses cell culture and rodent models.

Pathway and mechanistic context

Reports describe effects on cell survival, migration and the formation of new blood vessels in vitro, including activation of the VEGFR2 pathway and changes in focal adhesion signaling in migrating cells.

Preclinical summary

Tendon-fibroblast studies report increased outgrowth, survival and migration of cells. Endothelial cell studies report proliferation and tube formation. These are laboratory findings and do not establish effects outside the model used.

Form and analytical testing

Supplied as a lyophilized powder. Identity and purity are normally confirmed by HPLC and mass spectrometry. Refer to the Certificate of Analysis for the lot you receive.

References

1. Huang T. et al. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015;9:2485-2499. Source
2. Chang C-H. et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774-780. Source
3. Hsieh M-J. et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med. 2017;95(3):323-333. Source
4. Seiwerth S. et al. BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing. Curr Pharm Des. 2018;24(18):1972-1989. Source
5. Sikiric P. et al. Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157. Vascular recruitment and gastrointestinal tract healing. Curr Pharm Des. 2018;24(18):1990-2001. Source
6. Hu Y-L. et al. FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells. Sci Rep. 2014;4:6024. Source

Peptides are shipped lyophilized (freeze-dried), a state that keeps them stable in transit. Keep vials cold and away from light on arrival.

• Short term: refrigeration below 4°C (39°F) is generally suitable for lyophilized material held for days to months.
• Long term: a freezer at -80°C (-112°F) is preferred for storage over several months or years.
• After reconstitution: keep the vial refrigerated. Reconstituted material is generally kept for up to 30 days.