CJC-1295 No DAC/Ipamorelin

This is a research blend of CJC-1295 (no DAC, a modified GRF 1-29 analog) and ipamorelin, a synthetic pentapeptide. It is supplied as a lyophilized powder for laboratory research use only.

Research applications

The blend is used in studies of growth hormone axis signaling through two receptors, GHRHR and GHSR-1a. Topics include pulsatile hormone signaling, receptor cross-talk, and cAMP and calcium second-messenger pathways.

Pathway and mechanistic context

CJC-1295 acts on GHRHR through Gs signaling, which raises intracellular cAMP and activates PKA. Ipamorelin acts on GHSR-1a through PLC signaling and calcium release inside the cell.

Preclinical summary

Cell and animal studies have looked at GHRH analogs and ghrelin receptor agonists for receptor selectivity and for the timing of hormone release. All of the findings come from non-clinical laboratory models.

Form and analytical testing

Supplied as a lyophilized powder. Identity and purity are normally confirmed by HPLC and mass spectrometry. Refer to the Certificate of Analysis for the lot you receive.

References

1. K. Raun et al., “Ipamorelin, the first selective growth hormone secretagogue,” Eur. J. Endocrinol., vol. 139, no. 5, pp. 552–561, Nov. 1998. Source
2. N. B. Andersen, K. Malmlöf, P. B. Johansen, T. T. Andreassen, G. Ørtoft, and H. Oxlund, “The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats,” Growth Horm. IGF Res., vol. 11, no. 5, pp. 266–272, Oct. 2001. Source
3. J. Svensson et al., “The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats,” J. Endocrinol., vol. 165, no. 3, pp. 569–577, Jun. 2000. Source
4. B. Greenwood-Van Meerveld, K. Tyler, E. Mohammadi, and C. Pietra, “Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus,” J. Exp. Pharmacol., vol. 4, pp. 149–165, Oct. 2012. Source
5. M. Alba et al., “Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse,” Am. J. Physiol. Endocrinol. Metab., vol. 291, no. 6, pp. E1290-1294, Dec. 2006. Source
6. M. Ionescu and L. A. Frohman, “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog,” J. Clin. Endocrinol. Metab., vol. 91, no. 12, pp. 4792–4797, Dec. 2006. Source

Peptides are shipped lyophilized (freeze-dried), a state that keeps them stable in transit. Keep vials cold and away from light on arrival.

• Short term: refrigeration below 4°C (39°F) is generally suitable for lyophilized material held for days to months.
• Long term: a freezer at -80°C (-112°F) is preferred for storage over several months or years.
• After reconstitution: keep the vial refrigerated. Reconstituted material is generally kept for up to 30 days.