KLOW

KLOW is a research blend of four peptides: BPC-157, TB-500 (thymosin beta-4), KPV, and GHK-Cu. It is supplied as an 80 mg lyophilized powder for laboratory research use only.

Research applications

The blend suits studies that compare or combine four peptides in cell and animal models. Topics include inflammatory cytokine signaling, nitric oxide signaling, cell migration, and extracellular matrix activity.

Pathway and mechanistic context

BPC-157 is linked to nitric oxide signaling, TB-500 to actin binding, and GHK-Cu to copper binding and matrix remodeling. KPV, a short fragment related to alpha-MSH, is studied for its effect on inflammatory signaling molecules such as TNF-alpha.

Preclinical summary

Published work covers each peptide separately, in cell cultures and rodent models. Studies of the four together are limited, and the findings noted here are laboratory and animal-model results only.

Form and analytical testing

Supplied as a lyophilized powder. Identity and purity are normally confirmed by HPLC and mass spectrometry. Refer to the Certificate of Analysis for the lot you receive.

References

1. M.-J. Hsieh et al., “Modulatory effects of BPC 157 on vasomotor tone and the activation of Src-Caveolin-1-endothelial nitric oxide synthase pathway,” Sci Rep, vol. 10, no. 1, p. 17078, Oct. 2020, doi: 10.1038/s41598-020-74022-y. Source
2. M. Józwiak, M. Bauer, W. Kamysz, and P. Kleczkowska, “Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review,” Pharmaceuticals, vol. 18, no. 2, Art. no. 2, Feb. 2025, doi: 10.3390/ph18020185. Source
3. Y. Xing, Y. Ye, H. Zuo, and Y. Li, “Progress on the Function and Application of Thymosin β4,” Front Endocrinol (Lausanne), vol. 12, p. 767785, Dec. 2021, doi: 10.3389/fendo.2021.767785. Source
4. T. Brzoska, T. A. Luger, C. Maaser, C. Abels, and M. Böhm, “Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases,” Endocr. Rev., vol. 29, no. 5, Art. no. 5, Aug. 2008, doi: 10.1210/er.2007-0027. Source
5. M. Cutuli, S. Cristiani, J. M. Lipton, and A. Catania, “Antimicrobial effects of alpha-MSH peptides,” J Leukoc Biol, vol. 67, no. 2, Art. no. 2, Feb. 2000, doi: 10.1002/jlb.67.2.233. Source
6. L. Pickart and A. Margolina, “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data,” Int J Mol Sci, vol. 19, no. 7, p. 1987, Jul. 2018, doi: 10.3390/ijms19071987. Source

Peptides are shipped lyophilized (freeze-dried), a state that keeps them stable in transit. Keep vials cold and away from light on arrival.

• Short term: refrigeration below 4°C (39°F) is generally suitable for lyophilized material held for days to months.
• Long term: a freezer at -80°C (-112°F) is preferred for storage over several months or years.
• After reconstitution: keep the vial refrigerated. Reconstituted material is generally kept for up to 30 days.