Thymosin Alpha-1

Thymosin Alpha-1 (thymalfasin) is a 28-amino-acid peptide first isolated from thymus tissue. It is studied in immunology research, mainly for its effects on T-cell and dendritic-cell signaling.

Research applications

Thymosin Alpha-1 is used in laboratory studies of immune signaling, cytokine release and dendritic-cell maturation. Published work has also examined it in neurodevelopment, inflammation and cancer-cell models. This product is sold for laboratory research use only.

Pathway and mechanistic context

The literature describes the peptide acting through Toll-like receptor signaling in dendritic cells and influencing T-helper cell activity and cytokine production. Cell studies also report effects on CD8 T-cell factors and on pro-inflammatory mediators such as TNF-alpha and IL-1beta.

Preclinical summary

Mouse studies have examined immune reconstitution in thymus-deficient animals, neurogenesis and maze learning, and inflammatory pain markers. Cell-line work has measured proliferation and migration of lung epithelial cells. These are laboratory and model findings.

Form and analytical testing

Supplied as a lyophilized powder. Identity and purity are normally confirmed by HPLC and mass spectrometry. Refer to the Certificate of Analysis for the lot you receive.

References

1. R. King and C. Tuthill, “ Immune Modulation with Thymosin Alpha 1 Treatment ,” Vitam. Horm., vol. 102, pp. 151–178, 2016. Source
2. G. Wang et al., “ Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias ,” Neurosci. Bull., vol. 33, no. 6, pp. 675–684, Dec. 2017. Source
3. L. Romani et al., “ Thymosin α 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling ,” Blood, vol. 103, no. 11, pp. 4232–4239, Jun. 2004. Source
4. L. Romani et al., “ Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance ,” Ann. N. Y. Acad. Sci., vol. 1112, pp. 326–338, Sep. 2007. Source
5. Y. Xu et al., “ Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord ,” Neurosci. Bull., Feb. 2019. Source
6. L. Romani et al., “ Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis ,” Nat. Med., vol. 23, no. 5, pp. 590–600, May 2017. Source

Peptides are shipped lyophilized (freeze-dried), a state that keeps them stable in transit. Keep vials cold and away from light on arrival.

• Short term: refrigeration below 4°C (39°F) is generally suitable for lyophilized material held for days to months.
• Long term: a freezer at -80°C (-112°F) is preferred for storage over several months or years.
• After reconstitution: keep the vial refrigerated. Reconstituted material is generally kept for up to 30 days.